NIH P01: Prostate Cancer Bone Metastasis: Biology and Targeting
Models for Predicting PCa Progression (MPPP)
Under the direction of Dr. Leland W. K. Chung, the molecular understanding of the urologic disease process and therapeutic targeting are featured in the Molecular Urology and Therapeutics (MUT) Program. Leaders of five areas of research emphasis are identified:
- Mechanisms
of tumor-stroma interaction (Leland W. K. Chung, Ph.D.)
- Signaling
transduction, gene promoter studies and molecular targeting (Wen-Chin Huang, Ph.D.)
- Developmental
mechanisms stromal-epithelial interaction (Ruoxiang Wang.
M.D., Ph.D.)
- Elucidating
and targeting the aberrant signal transduction pathways implicated in
prostate cancer bone metastasis (Daqing Wu, Ph.D.)
- Steroid
receptor axis in cancer progression (Haiyen E. Zhau, Ph.D.)
Opportunities are provided to students and trainees to participate in
interactive research collaborations among the above described research
programs in the following areas:
- Extracellular
matrix integrin signaling in cancer progression
- Molecular
targeting at antiangiogenic and transcription factor pathways for cancer
metastasis
- Development
of novel imaging animal models for the study of cancer growth and metastasis
- Novel
genes involved in normal development, cell transformation and neoplastic
progression
- Androgen
receptor axis in hormone refractory prostate cancer
For more information, please contact the investigator by email or call (404) 778-4319.